ORC1 and neoplasm: To demonstrate the clinical relevance of candidate genes, which we identified by gene array analysis, we utilized TCGA public database and identified the availability of expression data paired with clinical data for DDIT4/REDD1, which is involved in cell growth, proliferation and survival; TSC1, which acts as a tumor suppressor; MCM6, which is involved in the cell cycle and DNA replication; and ORC1, which is involved in the initiation of DNA replication.