Future work should also examine how the ability of RBM8A to activate STAT3/Notch relates to the other functions of RBM8A within the EJC (15, 24), which include downregulating the pro-apoptotic factor Bcl-x in colon and prostate cancer cells and downregulating p53 in a range of tumor cells (45, 49). Here, STAT3 is linked to Familial prostate cancer.