Compared with normal tissues, the expression of ADM2, CLIC6, KIF20A, LAD1, MUC5B, and TNS4 was up-regulated, and the expression of ATG16L2, KCNK3, MAFF, NKD1, and SPATA13 was down-regulated in lung cancer tissues. The gene discussed is SPATA13; the disease is lung carcinoma.