ESR1 and neoplasm: NLGN2 was highly expressed in 75% (75/100) of the tumor samples, and its expression level was significantly associated with tumor size, lymph node metastasis, TNM stage and histological grade (all p < 0.05), but not with patient age or the expression levels of ER, PR and HER2 (all p > 0.05) (Figure 5 and Table 1).