As previous findings show, hepatic expression of FXR is impaired during some liver pathological conditions such as hepatocellular carcinoma (Su et al., 2012 ▶), alcoholic- cholestasis (Manley and Ding, 2015 ▶) and nonalcoholic steatohepatitis (Armstrong and Guo, 2017 ▶). This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatohepatitis.