AKT1 and Hepatic fibrosis: For instance, it has been suggested that naringin could operate as a protective and therapeutic factor in liver fibrosis through inhibition of reactive oxygen species generation, suppression of PI3K/Akt signaling-mediated cell survival, up-regulation of anti-inflammatory cytokines, and down-regulation of the profibrotic cytokines (El-Mihi et al., 2017 ▶).