Puimège et al. found that TNFR1 is ubiquitously expressed on most cells, while TNFR2 has a limited expression which is immunoregulatory [17]. Madsen et al. also presented similar findings, “multiple sclerosis is associated with pro-inflammatory effects of solTNF mediated through TNFR1,” while TNFR2 promotes repair and remyelination [21]. This evidence concerns the gene TNFRSF1A and multiple sclerosis.