TNF and inflammatory bowel disease: SF-36 Health Survey: Short form health survey; EQ-5D Health Survey: EuroQol- 5 dimension health survey; CRP: C-reactive protein; IL: Interleukin; TNF: Tumor necrotic factor; IBDQ score; Inflammatory bowel disease questionnaire score; PGAS score: Physician global assessment scores; NRS: Numerical rating scale; ITT: Intention to treat analysis;  PP: per-protocol analysis.