CDH1 and cancer: Physiologically, E-cadherin/β-catenin complex is required to maintain the integrity of epithelial cell-cell contact, keeps Wnt/β-catenin signals in check, and is involved actively in epithelial-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) which plays an important role in embryo development, tissue fibrosis, and cancer progression [12].