In SRCC of gastric origin and breast lobular carcinoma, E-cadherin plays a central role in the pathogenesis, and hereditary loss of CDH1, a tumor suppressor gene encoding E-cadherin protein, is one of the known pathogenic mechanisms for this disease which correlates well with loss of E-cadherin expression by immunohistochemical evaluation [11]. Here, CDH1 is linked to neoplasm.