CD44 and cancer: In the histopathological type of NPC, 90% is aggressive SCC, with a high recurrence cancer rate.25 In the case of oropharyngeal SCC, it was reported that there was a 39.4% decrease in CD44 isoform expression against the CD44 immunoreactivity criteria, and direct relationship between CD44 expression and cervical lymph node metastases, survival, and recurrence was not found in patients with significantly weak/negative CD44 expression.