There are numerous studies about the involvement of chemerin in diabetic complications (22-27) and the effects of α-LA in diabetic neuropathy (24, 28-47) and DN (48-50), but to our knowledge, there have been no previous studies that investigated the effect of α-LA in chemerin-induced human mesangial cell injury and the underlying mechanisms. Here, RARRES2 is linked to liver dysplastic nodule.