There are studies about the effects of chemerin in diabetic complications (22-27), as well as on the effects of α-LA in diabetes (24, 28-50) (of note, most studies of the effects of α-LA are about diabetic neuropathy, not DN), but to our knowledge, there have been no previous studies that investigated the effect of α-LA in chemerin-induced human mesangial cell injury and the underlying mechanisms. The gene discussed is RARRES2; the disease is diabetes mellitus.