SCARB1 and cancer: An inverse relation between HDL levels and cell proliferation and metastasis has been reported (58), although, the tumorigenic effect of HDL in cancer cells has been supported (59, 60) This conflicting data on the important role of SR-B1/HDL in the regulation of cell growth could be clarified by tissue specificity or other possible molecular mechanisms that are probably involved in the SR-B1 signaling pathway.