The haplotype analysis showed that the combination T-T of rs3826392 (-1304 T>G) and rs3809728 (-1044 A>T) alleles in the MKK4 gene increased the risk for developing CRC (OR=1.82; 95% CI=1.19-2.79, P=0.007) (Table 6). Here, MAP2K4 is linked to colorectal carcinoma.