TGFB1 and Hepatic fibrosis: Moreover, in a mouse model of NASH, naringenin administration could suppress hepatic steatosis, reduced hepatic oxidative stress and inflammation, and prevented liver fibrosis, as evidenced by the decrease in hepatic collagen deposition and hydroxyproline content, as well as by the reduction of protein expression of TGF-β1 and α-SMA in the liver.