In a study of diabetic nephropathy (DN), Yan et al. suggested that naringenin could inhibit the expressions of ECM components in both kidney tissues of DN rats and glomerular mesangial cells treated by high glucose and also inhibited mesangial cell proliferation, by suppressing TGF-β1/Smad signaling pathway via the regulation of microRNA let-7a [115]. This evidence concerns the gene TGFB1 and liver dysplastic nodule.