After OVA sensitization, a rat model of asthma was produced; in asthmatic animals, total WBC, percentages of eosinophil and neutrophil, and BALF levels of PLA2, TP, IgE, IL-4, NO2, NO3, and MDA were increased while lymphocyte percentage, IFN-γ/IL-4 ratio, and IFN-γ, SOD, CAT, and thiol levels were decreased compared to control animals. The gene discussed is IL4; the disease is asthma.