Curcumin downregulated IL-4 and IL-5 levels but upregulated IFN-γ in the BALF of a murine model of asthma [50] and attenuated allergic airway inflammation by modifying the balance of CD4‏+ CD25+ regulatory T cells (Tregs)/T-helper (Th) in ovalbumin (OVA)-sensitized mice [53] dose-dependently. The gene discussed is CD4; the disease is asthma.