Univariate Cox regression and K-M survival analysis were used to analyze 20 DMM regulators in the meta and TCGA PRAD cohort, which showed that DNMT3B, UHRF1, UNG, DNMT1, DNMT3A, MBD4, ZBTB38, MBD3, SMUG1, UHRF2, TDG, NTHL1, TET1, ZBTB4, and ZBTB33 were closely related to the DFS of patients with PCa (log-rank test: P < 0.05; Table S4). This evidence concerns the gene ZBTB4 and posterior cortical atrophy.