The interaction between SLX4 and XPF is critical for the repair of DNA interstrand crosslinks and a subset of Fanconi anemia patients harbor mutations in SLX4/FANCP (Kim et al., 2011; Stoepker et al., 2011; Schuster et al., 2013) or XPF/FANCQ (Bogliolo et al., 2013). The gene discussed is ERCC4; the disease is Fanconi anemia.