There is considerable interest in understanding the biological roles of SLX4IP, and valuable insights may come from studying patients, tissues and cells that have altered expression or mutations of SLX4IP. For example, SLX4IP is over-expressed in Merkel cell carcinoma, a rare but aggressive type of non-melanoma skin cancer (Kotowski et al., 2019). This evidence concerns the gene SLX4IP and non-melanoma skin carcinoma.