Regarding the local regulation of histone acetylation, under deprivation conditions in brain tumors, nuclear-translocated ASCC2 binds to transcription factor EB (TFEB) and fuels histone acetylation from acetate specifically on the promoters of TFEB target genes responsible for lysosomal biogenesis and autophagy (Li et al., 2017). The gene discussed is TFEB; the disease is brain neoplasm.