CD8A and cancer: In addition, the immunotherapy-activated CD8+ T lymphocytes induce ferroptosis in cancer cells by downregulating genes (SLC7A11 and SLC3A2) that encode two subunits of the XC− system, and the molecular basis behind this phenomenon may be related to interferon (IFN)-γ-mediated transcriptional repression of SLC7A11 and SLC3A2 (Wang et al., 2019).