As shown in Figure 7B, the genetic alteration rates of the S100 gene family members in PAAD ranges from 0 to 16% individually (S100A1, 6%; S100A2, 9%; S100A3, 9%; S100A4, 13%; S100A5, 11%; S100A6, 10%; S100A7, 5%; S100A7A, 5%; S100A8, 6%; S100A9, 7%; S100A10, 14%; S100A11, 9%; S100A12, 6%; S100A13, 10%; S100A14, 16%; S100A16, 13%; S100B, 0%; S100G, 2.7%; S100P, 8%; S100Z, 3%). Here, S100A3 is linked to pancreatic adenocarcinoma.