As displayed in Figure 6, we found that the high transcriptional levels of S100A2 (Hazard ratio (HR) = 1.6, p = 0.025), S100A3 (HR = 1.6, p = 0.02), S100A5 (HR = 1.6, p = 0.031), S100A10 (HR = 1.9, p = 0.0017), S100A11 (HR = 1.6, p = 0.018), S100A14 (HR = 1.7, p = 0.014) and S100A16 (HR = 2.3, p = 5.6e-05) were significantly associated with poor OS in PAAD, while low mRNA expression of S100A1 (HR = 0.64, p = 0.032), S100B (HR = 0.57, p = 0.0079) and S100Z (HR = 0.61, p = 0.017) were associated with worse OS. This evidence concerns the gene S100A3 and pancreatic adenocarcinoma.