Although SOD1 usually has an anti-apoptotic effect, in DS the imbalance between the amount of the cytosolic isoform of SOD1 (increased) and the glutathione peroxidase (normal), induces intracellular accumulation of ROS and, consequently, oxidative stress, cell damage and apoptosis (Hasle, 2001; Ayed et al., 2012; Martel-Billard et al., 2016; Weizmann Institute of Science, 2020). Here, SOD1 is linked to Dravet syndrome.