The imbalance of DYRK1A and REST expression typical of DS results in premature differentiation of neuronal progenitor cells (Canzonetta et al., 2008; Lu et al., 2011; Dekker et al., 2014; Fernández-Martínez et al., 2015; Kay et al., 2016; Wang et al., 2018). The gene discussed is REST; the disease is Dravet syndrome.