This attenuation by DYRK1A overexpression is believed to have a tumor suppressive effect in solid tumors but, conversely, promote the development of some lymphoproliferative disorders, e.g., megakaryocytic malignancies in children with DS (Birger and Izraeli, 2012; Nižetić and Groet, 2012; Fernández-Martínez et al., 2015; Kay et al., 2016). This evidence concerns the gene DYRK1A and neoplasm.