Therefore, we highlighted the IL6ST/JAK/STAT pathway in the effect of LEPROT in cancer, which was profoundly involved in the proliferation of cancer cells, immune regulation, and CAF activation and function (Hirano et al., 2000; Carbia-Nagashima and Arzt, 2004; Yu et al., 2009; Calon et al., 2012; Amin et al., 2017; Jones and Jenkins, 2018; Biffi et al., 2019; Yang et al., 2020b; Cheteh et al., 2020). The gene discussed is IL6ST; the disease is cancer.