MSH6 and neoplasm: Notably, as tumor-suppressor genes, mismatch repair (MMR) genes constitute the MMR system that recognizes and repairs DNA mistakes (Marti et al., 2002; Putnam, 2016), six of which (MLH1, MLH3, MSH2, MSH3, MSH6, and PMS2) was overall positively correlated with LEPROT in mRNA expression.