Modeling of network modules by cluster analysis, associated X-ALD with the ABCD1-3 and PEX19 network motif, whereas PEX26 was grouped with all phenotypes of the Zellweger spectrum and phenotypes of deficient peroxisomal fission (PEX11B and DNM1L deficiency). The gene discussed is ABCD1; the disease is X-linked adrenoleukodystrophy.