In pediatric sarcoma, CAR-NK cells have shown anti-cancer activity in vitro. GD2-specific CAR-NK had an increased activity against EWS cells in an antigen-specific manner, but when transferred to mice with GD2-positive EWS xenografts they lacked efficiency due to inhibitory HLA-G hyper-expression on the tumor (56). Here, EWSR1 is linked to neoplasm.