With the increase in the understanding of modes of action, expression regulation of CCL2/CCR2 in various immune cells, other stromal cells, and cancer cells, and improved and versatile delivery platforms including multiple specific Ab as a single biologic, antibody drug conjugation and PROTAC, as well as identification of biomarkers with predictive value, we contend that there are still potential solutions to generating effective therapeutics targeting CCR2/CCL2 axis in cancer. This evidence concerns the gene CCR2 and cancer.