CCL2/CCR2 signaling also triggers the JAK/STAT pathway by activating Janus kinase 2 (JAK2) (61), and thereby triggers downstream pathways, including STAT1, STAT3, and STAT5 (62, 63), which further inhibit apoptosis and induce extravasation and expansion of tumor cells like colon carcinoma (64). The gene discussed is STAT3; the disease is neoplasm.