CD4 and cancer: As shown in Figure S10A, in the high-risk group, the release of cancer cell antigens increased during the cycle (step 1) but initiation and activation (step 3) and immune cell transport to tumors (step 4) (B cell recruitment, CD4 T cell recruitment, macrophage recruitment, T cell recruitment, Th2 cell recruitment, Th22 cell recruitment, DC recruitment and TH17 recruitment) decreased.