NR3C2 and hypertensive disorder: The diagnosis of PA is relevant, not only for its association to high blood pressure but also for the harmful effects in extra-renal tissues, generally associated with the mineralocorticoid receptor (MR) activation by aldosterone which induces inflammation (8, 9), tissue remodeling, and fibrosis (8, 10–14), affecting the renal, heart, the vascular system (endothelial cells and smooth muscles cells), the immune system (15) and the adipose tissue (16).