Therefore, by binding to these proteins, gC1qR can play an additional role in COVID-19 pathology by modulating the crosstalk between the complement and coagulation pathways through fibrin formation, immune injury and/or inflammation The fact that all of the major structural proteins bind gC1qR efficiently therefore suggests that SARS-CoV-2 could potentially use gC1qR as an alternate receptor for cellular entry and/or intercellular communication, thus making gC1qR a pluripotent target exploited by SARS-CoV-2. Here, C1QBP is linked to COVID-19.