Indeed, CCR2 knockout mice, which are largely deficient in classical monocytes in the periphery, show decreased levels of IL-1β and Tumor Necrosis Factor (TNF)-α and an increase in the anti-inflammatory cytokines IL-4, IL-5 and IL-13 at the site of inflammation during cerebral ischemia (83). The gene discussed is TNF; the disease is Cerebral ischemia.