Interestingly, hID2 lost its protective effect against colitis in the absence of neutrophils, and there were no significant differences in body weight, DAI scores or colon lengths among the DSS+αIgG group, DSS+αGr-1 group and DSS+αGr-1+hID2 group (Figures 9B–E). This evidence concerns the gene TXNDC12 and colitis.