IRF1 and colonic neoplasm: Transcription factors (TFs) enrichment heat map accomplished by SCENIC analysis (29) (Figure 3B) further substantiated that, compared with other subgroups, the immune-promoting TFs such as IRF1, IRF7, and STAT1 were enriched in C1QC+Macrophage (42–44), similar to Zhang et al.’s colon cancer observation (45).