At the same time, NEAT1, which is induced by estrogen in breast cancer, can form FOXN3-NEAT1-SIN3A inhibitory factor, through the interaction with FOXN3 and SIN3A protein complex, and promote epithelial-mesenchymal transformation (EMT) and metastasis, diffusion and invasion of breast cancer cells. The gene discussed is SIN3A; the disease is breast cancer.