As CB4-MDA5+/- mice have a burst in IFN-β shortly after infection that subsides by day 7 post-infection, it is likely that controlled, local, IFN-β signaling at the site of the islet β cell, leads to protection from exacerbated autoreactive responses and ensuing autoimmunity. The gene discussed is IFNB1; the disease is Autoimmunity.