Similar to MDA5+/- mice (13), at day 7 following CB4 infection in comparison to wt mice, TLR3+/- mice have significantly increased regulatory Foxp3+ T cells in the pancreatic lymph nodes (PLNs) and in the spleen, while statistical significance was not achieved, there was a propensity for increased Tregs (Figure 2A). The gene discussed is TLR3; the disease is infection.