TLR3 and infection: TLR3+/- mice have three times the amount of IFN-β than IFN-α in the sera at baseline, prior to CB4 infection, compared to wt mice and by day 3 post infection, TLR3+/- mice dramatically lose IFN-β production versus IFN-α in the sera (ratio of 0.14) compared to wt mice (ratio 0.71, Figure 1C).