TLR3 expression, at reduced levels in TLR3+/- mice, is not successful in protecting from CB4-induced T1D (Figure 1B) as up to 16 days post-infection, TLR3+/- mice show a higher incidence of T1D compared to infected control wild type TLR3+/+ mice. Here, TLR3 is linked to type 1 diabetes mellitus.