Infection with the non-diabetogenic non-beta cell tropic virus CB3 in MDA5+/- mice, however, induces a more inflammatory response with the increased presence of both regulatory Foxp3+ CD4+ T cells and effector CD44hiCD62Llo CD4+ T cells at the site of autoimmunity, in the pancreatic lymph nodes (PLNs) (Figure 3B) compared to infected wt mice. This evidence concerns the gene IFIH1 and infection.