In summary, the increased killing capacity of GD2+ target cells, the enhanced secretion of NK cell-specific cytokines, and the upregulation of CD107a in modified NK-92 cells cocultivated with GD2+ target cells and the upregulation of Annexin V in GBM demonstrated an antigen-specific cytolytic activity of NK cells mediated by GD2CAR. Here, LAMP1 is linked to glioblastoma.