TGFB1 and neoplasm: On the contrary, the regulatory T cells (Tregs) can secrete inhibitory cytokines, such as transforming growth factor (TGF)-β and interleukin (IL)-10, contributing to LC progression via angiogenesis and immunosuppression through inhibition of the anti-tumor effect of T-helper (Th1) cells as well as attracting activated Th2 cells (7–10).