It was found that corresponding genes of DMPs were concentrated in the cytokine-receptor pathways such as TGF−beta Receptor (TGF-β), TP53, tumor necrosis factor-alpha (TNFα), and interleukin-2(IL-2), which implied a strong relationship between glioma tissues and inflammatory responses (Figure 2D). This evidence concerns the gene TGFB1 and central nervous system cancer.