On the other hand, a significantly higher ratio of bacteremia was observed in TRPV4 KO mice (15 out of 31 mice, 48.4%) compared with wild-type (3 out of 20 mice, 15%) and with TRPV1 KO mice (4 out of 14 mice, 28.6%) by high-dose inoculation (Table 1). This evidence concerns the gene TRPV4 and bacterial infectious disease with sepsis.