Importantly, adoptive transfer (AT) of Peyer’s patches (PP)-derived wild-type (WT) B cells, but not Itgam−/− (CD11b KO) B cells, inhibited colitis in Cd79a−/− B cell-deficient mice, suggesting that CD11b is indispensable for the regulatory function of GALT B cells. The gene discussed is ITGAM; the disease is colitis.