AR and viral infectious disease: TMPRSS2, a well-known AR-responsive gene, emerged as hot topics in COVID-19 by processing a universal proteolytical activating effect to coronavirus family and influenza virus (Kawase et al., 2012; Böttcher-Friebertshäuser et al., 2014; Yamamoto et al., 2016; Shen et al., 2017; McKee et al., 2020), thus emphasize the requirement to fully elucidate the molecular mechanisms which underling the sex disparity in several viral infectious diseases.