Chemerin appears to directly add to the antimicrobial effect of p4 and/or indirectly facilitate p4 anti-staphylococcal action on the skin, as suggested by more effective control of S. aureus growth in WT mice compared to ChemKO mice observed in both in vivo and ex vivo models of skin infection (Figures 2, 3 and Table 2). This evidence concerns the gene RARRES2 and skin infection.