The metagenomic change intersection in HBP patients and wild-type hypertension mice was further filtered by metagenomic changes in AMPK-knockout hypertension mice, as described in the section “Results.” By such strategy, we found that among significantly changed bacteria in HBP patients, Dorea could be inhibited by macrophage-AMPK mechanism in HBP patients. Here, PRKAA1 is linked to hypertensive disorder.