To test such probability, we further used wild-type and macrophage-specific AMPK-knockout mice to make AngII-induced hypertension model, and we compared the intersection of metagenomic changes in mice and hypertension (HBP) patients, so as to uncover the potential macrophage-AMPK-regulated metagenomic components in the investigated HBP patients. The gene discussed is PRKAA1; the disease is hypertensive disorder.