To date only one patient with CIADM has had pancreatic histopathology reported, a 63 year old man with renal cell carcinoma and pre-existing type 2 diabetes whom developed diabetic ketoacidosis and low C-peptide after treatment with combination anti-CTLA4/PD-1 therapy (49). This evidence concerns the gene PDCD1 and hereditary clear cell renal cell carcinoma.