Over 20% of responder centers reported shortages of several supplies specific for diabetes, HH, adrenal, and bone metabolism disorders: glucose test stripes (14.1%), blood glucose sensors (12.4%), basal (11.5%) and bolus (10.6%) insulin, diazoxide (19.5%), hydrocortisone (25.7%), and calcitriol (9.4%). The gene discussed is INS; the disease is metabolic bone disorder.