A pooled analysis of two multicenter, randomized, noncomparative, phase 2 clinical trials (HORGEN and CARMINA02) evaluating neoadjuvant anastrozole and fulvestrant efficacy for postmenopausal HR+/HER2- breast cancer indicated that PEPI can identify a subset of patients with poorer prognosis who should be offered all appropriate adjuvant therapy (55). The gene discussed is ERBB2; the disease is breast cancer.