Sixteen-week exercise (dose recommendations based on the Ainsworth Compendium of Physical Activities) with at least four 40-min homework exercise sessions per week, consisting of at least moderate physical activity, increases the production of the anti-inflammatory cytokine IL-10 and reduces the production of proinflammatory cytokines, proinflammatory markers, and cytokines such as C-reactive protein (CRP) and IL-6 in MDD, which may be the mechanism of its antidepressant effect of depression (75). This evidence concerns the gene IL6 and major depressive disorder.