In a study performed in a rat model of diabetes in pregnancy induced by STZ administration on day 12 of gestation, the heart of the 6-week-old offspring showed an increase in NOX1 and NOX2 together with an increase in reactive oxygen species in the left ventricle (Chen et al., 2019), and the heart of adult offspring still showed an increase in NOX2 expression (Zhang et al., 2018). This evidence concerns the gene CYBB and diabetes mellitus.