EZH2 and gestational diabetes: EZH2β is part of a multisubunit complex that initiates and maintains the trimethylation of histone H3 on lysine 27 (H3K27me3), an epigenetic mark associated with heterochromatin formation and gene silencing (Cao et al., 2002), and thus probably related to the regulation of this epigenetic mark in endothelial cells from GDM offspring.