FOXO1 and diabetes mellitus: In a study of a rat model of STZ-induced mild diabetes, the heart of adult offspring showed a reduction in mTOR protein levels and in the phosphorylation of serum- and glucocorticoid-inducible kinase 1 (SGK1), a downstream target of the mTORC2 pathway, which phosphorylates FoxO1 (Musikant et al., 2019).