SIRT1 and diabetes mellitus: In a rat model of diabetes in pregnancy induced by STZ administration on day 12 of gestation, cardiomyocytes from 6-week-old offspring showed an increase in global DNA methylation status, together with an increase in the cardiac expression of DNA methyltransferase 3A and reduced expression of the silent information regulator 1 (Sirt1), a class III histone deacetylase (Chen et al., 2019).