EIF2AK2 and Schnyder corneal dystrophy: Shrestha et al. (2021) demonstrated that SCD-modeling “Berk” mice given the orally available PKR activator FT-4202 (etavopivat) for 2 weeks had significantly increased ATP and reduced 2,3-DPG, improved deformability, lower susceptibility to deoxygenation-induced sickling and rigidity, and attenuated indices of hemolysis.