Although a potential role for modulating MR activity to treat cancer was demonstrated in a variety of cell types (Shah et al., 2009), except for an ongoing trial to investigate the utility of bethanechol before surgery for resectable PDAC (U.S. National Library of Medicine, 2021), the efficacy of modulators of MR activity in digestive tract cancers has not been tested in the clinic. The gene discussed is NR3C2; the disease is cancer.