Indeed, because of the multifactorial pathophysiology of both dry and wet AMD, we designed an integrated in vitro model of AMD, stimulating RPE cells with three different challenges: Aβ oligomers, hydrogen peroxide (H2O2), and inflammatory stimuli (LPS and TNF-α), and testing the effects of in vitro treatment with anti-inflammatory, anti-angiogenic, and antioxidant molecules: 1,25(OH)2D3 (vitamin D3), meso-zeaxanthin (MZ), and their combination. Here, TNF is linked to age-related macular degeneration.