TNF and Alzheimer disease: The pathogenesis of AD is complex and multifactorial, hence the goal of pharmacotherapy should be to influence a number of proteins and enzymes, including NMDA, nitric oxide synthase (NOS), beta secretase 1 (BACE-1), TNFα, mono amine oxidase A (MAO-A), mono amine oxidase B (MAO-B) and butylcholine esterase (Grewal et al., 2020).